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Brain Tumor Talk Ep. 7: Breaking Down Biomarkers
In this episode of Brain Tumor Talk, we explore biomarker testing, a critical aspect of brain tumor diagnosis and treatment. With the 2021 World Health Organization (WHO) classification of brain tumors spotlighting the importance of molecular biomarkers, it’s more important than ever for patients to understand how tumor profiling can guide treatment options. Shwetal Mehta, PhD, and Charuta Furey, MD, join us to simplify the science and break down everything you need to know about biomarker testing.
For years, doctors graded brain and spinal cord tumors primarily by looking at cell samples under a microscope. But now, unique molecular markers offer significant insights to help predict outcomes and tailor treatment to each patient. Despite this advancement, many patients remain in the dark; a recent National Brain Tumor Society survey found that nearly 70% don’t fully understand biomarker testing. This episode dives into the essentials so you feel empowered to discuss this with your care team.
In this Episode, You’ll Hear
- The types of biomarkers and their functions
- How tumor profiling influences treatment planning
- Key questions to ask your physician about biomarker testing
- How biomarker results can connect you to clinical trials and targeted therapies
What to listen for:
1:22: What is a biomarker?
3:25: Pathology, genetic, and biomarker testing—key differences
7:08: Understanding MGMT methylation
8:07: Essential treatment questions for your doctor
8:55: What is IDH status?
14:13: The benefits of biomarker testing
17:09: Using biomarker results after recurrence to explore clinical trial options
20:10: Resources for finding trials and alternative therapies
36:25: The latest advancements on the horizon
38:57: Dr. Mehta’s rapid-fire questions
40:50: Dr. Furey’s rapid-fire questions
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